Acoustic holography
3D-printed holographic lenses are designed for high-fidelity volumetric beam shaping, enabling complex targets without hundreds of sequential sonications.
Focused ultrasound brain-access platform
Brain access without the MRI bottleneck.
HoloSoniq is developing a portable, MRI-free focused ultrasound platform designed to enable targeted, repeatable delivery of therapeutics across the blood-brain barrier.
The delivery problem
Promising CNS therapies need a better route to the target.
Many promising CNS programs are limited less by therapeutic concept than by delivery. The broader vision is a universal brain-access infrastructure layer for drugs, biologics, gene therapies, cell therapies, and next-generation neurotherapeutics.
How it works
Three technology pillars, one deployable workflow.
Predictive control
Machine-learning models use passive cavitation signals to anticipate microbubble instability and support safer, more reproducible blood-brain barrier opening.
MRI-free navigation
Nonlinear acoustic feedback, optical registration, and robotic positioning are being integrated to reduce reliance on specialized MRI-guided treatment suites.
Development status
Built from de-risked research pillars.
Validated components
NIH- and NSF-supported work has demonstrated accurate transcranial targeting, localized barrier opening, and enhanced therapeutic delivery in preclinical studies.
Protected platform
The intellectual property portfolio includes issued U.S. patents and pending applications around ultrasound focusing, acoustic holograms, and ML control.
Translational focus
The current milestone is an integrated prototype for phantom, rodent, ex vivo skull, and large-animal validation on the path toward first-in-human readiness.
What comes next
A practical path from research platform to clinical translation.
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Prototype integration
Combine holographic lenses, robotic positioning, passive cavitation detection, and control software.
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Preclinical validation
Run water-tank, phantom, rodent, ex vivo human-skull, and large-animal studies.
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Regulatory engagement
Define safety, software, manufacturing, and performance evidence with FDA CDRH feedback.
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Partner deployments
Collaborate with translational research centers, academic labs, and CNS therapeutic developers.
Collaborate
We are building with clinical, research, and industry partners.
HoloSoniq is seeking conversations with focused ultrasound researchers, CNS therapeutic developers, translational funders, research centers, and strategic medical-technology partners.